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2012 Fiscal Year Final Research Report

Analysis of calcium-signaling cascade in the regulation of spermfunction using gene-modified animals

Research Project

  • PDF
Project/Area Number 23800038
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Laboratory animal science
Research InstitutionOsaka University

Principal Investigator

MIYATA Haruhiko  大阪大学, 免疫学フロンティア研究センター, 特任助教 (50604732)

Project Period (FY) 2011 – 2012
Keywords受精 / 精子 / カルシウム
Research Abstract

I made a knockout(KO) mouse that lacks testis-specific calcineurin to understand its role in the regulation of sperm fertilizing ability. As a result, I found that calcineurin is important to maintain sperm motility and is necessary for fertilization. There were no problems found in the morphology of KO sperm. I also made a knockout mouse that lacks testis-specific calpain that is a calcium-dependent enzyme like calcineurin.

  • Research Products

    (4 results)

All 2013 2012 2011 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (2 results) Remarks (1 results)

  • [Journal Article] Protease activation and the signal transduction pathway regulating motility in sperm from the water strider Aquarius remigis2012

    • Author(s)
      Miyata, H., Thaler, CD., Haimo, LT., Cardullo RA.
    • Journal Title

      Cytoskeleton

      Volume: 69(4)巻 Pages: 207-220

    • Peer Reviewed
  • [Presentation] 雌性生殖路を移行する精子のin vivoライブイメージング2013

    • Author(s)
      宮田治彦
    • Organizer
      第3回vivid workshop
    • Place of Presentation
      石川県加賀市
    • Year and Date
      2013-02-22
  • [Presentation] アメンボ精子の運動様式と運動開始調節機構2011

    • Author(s)
      Miyata, H., Thaler, CD., Haimo, LT., Cardullo RA
    • Organizer
      日本動物学会第82回大会
    • Place of Presentation
      神楽公民館(旭川市)
    • Year and Date
      2011-09-21
  • [Remarks] 大阪大学微生物病研究所遺伝子機能解析分野ホームページ

    • URL

      http://www.egr.biken.osaka-u.ac.jp/

URL: 

Published: 2014-08-29  

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