2012 Fiscal Year Final Research Report
Analysis of calcium-signaling cascade in the regulation of spermfunction using gene-modified animals
| Project/Area Number |
23800038
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Laboratory animal science
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| Research Institution | Osaka University |
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Principal Investigator |
MIYATA Haruhiko 大阪大学, 免疫学フロンティア研究センター, 特任助教 (50604732)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 受精 / 精子 / カルシウム |
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| Research Abstract |
I made a knockout(KO) mouse that lacks testis-specific calcineurin to understand its role in the regulation of sperm fertilizing ability. As a result, I found that calcineurin is important to maintain sperm motility and is necessary for fertilization. There were no problems found in the morphology of KO sperm. I also made a knockout mouse that lacks testis-specific calpain that is a calcium-dependent enzyme like calcineurin.
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