2012 Fiscal Year Final Research Report
Drug delivery to redox-disease site using an artificial virus
| Project/Area Number |
23800045
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Kyushu University |
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Principal Investigator |
TOITA Riki 九州大学, 歯学研究院, 助教 (40611554)
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| Project Period (FY) |
2011 – 2012
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| Keywords | ナノバイオ / 医療・福祉 / バイオテクノロジー |
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| Research Abstract |
Traditional drug carriers do not have sufficient selectivity to disease cells. In this research, a naturally occurring protein cage, Hsp16.5, was fabricated to selectively deliver cargos into hepatoma cells through chemical and genetic methods. Resulting fabricated Hsp16.5 cages were selectively taken up by hepatoma cells, but not by normal hepatocyte. When conjugate with doxorubicin (DOX) and hepatoma-targetable Hsp were added to hepatoma and normal hepatocyte, cytotoxicity of this conjugates to hepatoma was comparable with that of free DOX, whereas this conjugates drastically reduced cytotoxicity to normal hepatocyte.
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[Journal Article] Liver cell specific targeting by the preS1 domain of hepatitis B virus surface antigen displayed in protein nanocages2012
Author(s)
Masaharu Murata, Sayoko Narahara, Kaori Umezaki, Riki Toita, Shigekazu Tabata, Jing Shu Piao, Kana Abe, Joeng-Hun Kang, Kenoki Ohuchida, Lin Cui, Makoto Hashizume
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Journal Title
International Journal of Nanomedicine
Volume: 7
Pages: 4353-4362
URL
Peer Reviewed
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