2012 Fiscal Year Final Research Report
Understanding the molecular mechanism required for an anchorage-independent growth of CD133-positive ovarian cancer cells
| Project/Area Number |
23800055
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Tumor biology
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| Research Institution | Juntendo University |
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Principal Investigator |
ARAKI Marito 順天堂大学, 医学研究科, 准教授 (80613843)
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| Project Period (FY) |
2011 – 2012
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| Keywords | CD133 / 卵巣癌 / 足場非依存性 / がん幹細胞 |
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| Research Abstract |
Solid tumors are comprised of heterogeneous cells, which seem to play crucial roles in the establishment of drug-resistance and the recurrence of tumor. In this study, we identified genes highly expressed in CD133-positive ovarian cancer cells, named themHEG(Highly-expressed genes in CD133-positive cells), and showed that HEG1-3 play an important role for the anchorage-independent cell growth. Further studies would reveal more precise molecular mechanisms of the anchorage-independent cell growth in CD133-positive ovarian cancer cells.
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