2013 Fiscal Year Final Research Report
Development of Photo-polymerizable Molecular Glue for Brain Tumor Treatment
| Project/Area Number |
23850007
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional materials chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
OKURO Kou 東京大学, 工学(系)研究科(研究院), 助教 (60614360)
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| Project Period (FY) |
2011-08-24 – 2013-03-31
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| Keywords | 分子糊 / 光応答性 / フォトクリックケミストリー / 抗癌剤 |
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| Research Abstract |
"Photo-polymerizable molecular glue" having guanidinium ion, diaryltetrazole, and olefin was successfully synthesized. Photoirradiation to the monomeric glue resulted in the formation of polymeric molecular glue, which has high capability to adhere to the surface of biomacromolecules. In addition, based on a similar concept to the above, "photoclickable molecular glue", which can convert its non-covalent adhesion to covalent binding by light, was developed. Furthermore, another "photoresponsive molecular glue", which exerts mechanical force to the adhering surface, was also synthesized.
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