2012 Fiscal Year Final Research Report
Construction of artificial synapse liposome array using the vesicular transport liposome model
| Project/Area Number |
23850022
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemistry related to living body
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| Research Institution | 公益財団法人神奈川科学技術アカデミー (2012)
Kanagawa Academy of Science and Technology (2011) |
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Principal Investigator |
KAMIYA Koki 公益財団法人神奈川科学技術アカデミー, バイオマイクロシステムプロジェクト, 研究員 (70612315)
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| Project Period (FY) |
2011 – 2012
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| Keywords | リポソーム / リン脂質 / 人工細胞モデル / タンパク質 / ベシクル / 非対称膜 |
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| Research Abstract |
This study conducted the preparation of asymmetric cell-sized lipid vesicles from a planar lipid bilayer using pulsed jet flow. First, cell-sized vesicles (diameter of 5 μm in over 1 day) were stably formed using an improved double-well device wherein a separator with a 150-μm-hole diameter, was mounted between the wells. Moreover, asymmetric vesicles of phosphatidylserine lipids were successfully formed on each leaflet using this device. The asymmetric cell-sized lipid vesicles will create new opportunities for artificial cell research model such as the interactions between lipid membranes and proteins.
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