2012 Fiscal Year Final Research Report
Reconstitution of small RNA-induced silencing complex assembly
| Project/Area Number |
23870004
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Molecular biology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | RNA サイレンシング / Argonaute / 小分子 RNA / シャペロン |
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| Research Abstract |
Small RNA duplexes form the complex termed RISCs. So far, many studies have indentified the essential factors for this complex assembly pathway. However, the sufficient and minimal factors for RISC assembly have been remained unclear. Here, I established a reconstitution system for fly Ago2-RISC assembly. Results of this research project provide the fundamental and important framework for small RNAs, which are known to regulate diverse biological processes including diseases.
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