2012 Fiscal Year Final Research Report
Regulation of TOR complex 2 by Rab-family G proteins
| Project/Area Number |
23870019
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Cell biology
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| Research Institution | Nara Institute of Science and Technology |
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Principal Investigator |
SHIOZAKI Kazuhiro 奈良先端科学技術大学院大学, バイオサイエンス研究科, 教授 (00610015)
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| Project Period (FY) |
2011 – 2012
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| Keywords | TOR / TORC2 / Rab タンパク質 / 分裂酵母 |
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| Research Abstract |
TOR protein kinase forms two different complexes, one of which is TOR complex 2 (TORC2) that phosphorylates and activates the oncogene product Akt. Akt is known to play key roles in cell proliferation of mammalian early development as well as that of cancerous cells. In addition, the TORC2-Akt pathway mediates insulin signaling to induce glucose uptake in muscle and fat cells. Because TORC2 is highly conserved between human and the fission yeast Schizosaccharomyces pombe, this study utilized fission yeast as a model system to examine the regulatory mechanisms of TORC2 activity. Our results strongly suggest that small GTPases are involved in activation of TORC2. In addition, candidates of novel TORC2 activators have been identified through genetic screens.
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[Book] PP2C2012
Author(s)
建部恒、塩崎一裕
Total Pages
1450-1453
Publisher
Springer Science 社
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