2012 Fiscal Year Final Research Report
Investigation of the homeostatic regulation for organelle abundanceby invention of organelle knockdown-technology
| Project/Area Number |
23870020
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Cell biology
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| Research Institution | Nara Institute of Science and Technology |
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Principal Investigator |
YANAGITANI Kota 奈良先端科学技術大学院大学, バイオサイエンス研究科, 特任助教 (70614775)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 細胞生物学 / バイオテクノロジー / オルガネラ |
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| Research Abstract |
Organelle abundance in eukaryotic cells seems to be tightly regulated. These regulations, however, are poorly understood. The objective of this project was investigation of unknown homeostatic regulation of organelle abundance by invention of organelle-knockdown technology which reduces the amount of specific organelle. In this granted term, I could make a prototype of the organelle knockdown technology, although its efficiency was not high. This system will be applicable to investigation of the homeostatic regulation of organelle abundance by improvement of the system.
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[Journal Article] Reconstitution and characterization of the unconventional slicing of XBP1u mRNA in vitro2011
Author(s)
Shinya, S., Kadokura, H., Imagawa, Y., Inoue, M., Yanagitani, K., and Kohno, K.
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Journal Title
Nuc. Acids Res
Volume: 39
Pages: 5245-5254
DOI
Peer Reviewed
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