2012 Fiscal Year Final Research Report
Stress-induced NF-κB mediated by the nuclear IKKβandcelldeath
| Project/Area Number |
23870022
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional biochemistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
TSUCHIYA Yoshihiro 広島大学, 大学院・医歯薬保健学研究院, 特任助教 (90611301)
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| Project Period (FY) |
2011 – 2012
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| Keywords | NF-κB / 細胞内シグナル伝達 / ストレス応答 / アダプター / 炎症 |
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| Research Abstract |
We have found that nuclear IKKβ induces IκB degradation in UV- and oxidative stress-induced NF-κB activation. The administration of concanavalin A (ConA) and acetaminophen(APAP) to mice causes cell death and severe liver injury. Expression of IKKβ in the nucleus in IKKβ knockout mice greatly increases ALT levels and exhibited sever liver damage. These results suggested a possible involvement of nuclear IKKβ pathway in hepatitis.
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Research Products
(10 results)
