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2012 Fiscal Year Final Research Report

Investigation into the molecular mechanism of the resolution of glucocorticoid resistance in lymphoma.

Research Project

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Project/Area Number 23880009
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Clinical veterinary science
Research InstitutionTokyo University of Agriculture and Technology

Principal Investigator

MATSUDA Akira  東京農工大学, 農学府, 助教 (90613969)

Project Period (FY) 2011 – 2012
Keywordsリンパ腫 / グルココルチコイド耐性 / グルココルチコイド受容体 / NF-κB
Research Abstract

In this research, a novel mechanism of induction of glucocorticoid resistance in lymphoma cells was proposed by analyses of factors that could modulate the expression of glucocorticoid receptors. Furthermore, it was confirmed that inhibition of NF-κB could restore glucocorticoid sensitivity, suggesting that it may be a new strategy for the treatment of lymphoma with glucocorticoid resistance.

  • Research Products

    (34 results)

All 2013 2012 2011 Other

All Journal Article (15 results) (of which Peer Reviewed: 15 results) Presentation (17 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Heterogeneity of internal tandem duplications in the c-kit of dogs with multiple mast cell tumors2013

    • Author(s)
      Amagai Y, Akane T, Matsuda A, Oida K, Jung K, Nishikawa S, Jang H, Matsuda H
    • Journal Title

      J. Small Anim. Prac

      Volume: (In press)

    • DOI

      DOI:10.1111/jsap.12069.

    • Peer Reviewed
  • [Journal Article] Increased expression of the antiapoptotic protein MCL1 in canine mast cell tumors2013

    • Author(s)
      Amagai Y, Akane T, Matsuda A, Oida K, Jung K, Nishikawa S, Jang H, Ishizaka S, Matsuda H
    • Journal Title

      J. Vet. Med. Sci

      Volume: (In press)

    • DOI

      DOI:10.1292/jvms.13-0025.

    • Peer Reviewed
  • [Journal Article] Superselective intra-arterial chemoradiation therapy for functional laryngeal preservation in advanced squamous cell carcinoma of the glottic larynx2013

    • Author(s)
      Furusaka T, Matsuda A, Tanaka A, Matsuda H, Ikeda M
    • Journal Title

      Acta. Otolaryngol

      Volume: 133(6) Pages: 633-640

    • DOI

      DOI:10.3109/00016489.2012.759275.

    • Peer Reviewed
  • [Journal Article] The phosphoinositide 3-kinase pathway is crucial for the growth of canine mast cell tumors2013

    • Author(s)
      Amagai Y, Tanaka A, Matsuda A, Oida K, Jung K, Matsuda H
    • Journal Title

      J. Vet. Med. Sci

      Volume: (In press)

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/23328607

    • Peer Reviewed
  • [Journal Article] Laryngeal preservation in advanced piriform sinus squamous cell carcinomas using superselective intra-arterial chemoradiationtherapy with three agents2013

    • Author(s)
      Furusaka T, Matsuda A, Tanaka A, Matsuda H, Ikeda M
    • Journal Title

      Acta. Otolaryngol

      Volume: 133(3) Pages: 318-326

    • DOI

      DOI:10.3109/00016489.2012.744144.

    • Peer Reviewed
  • [Journal Article] Daily intake of Jeju ground water improves the skin condition of the model mouse for human atopic dermatitis2013

    • Author(s)
      Tanaka A, Jung K, Matsuda A, Jang H, Kajiwara N, Amagai Y, Oida K, Ahn G, Ohmori K, Kang K, Matsuda H
    • Journal Title

      J. Dermatol

      Volume: 40(3) Pages: 193-200

    • DOI

      DOI:10.1111/1346-8138.12055.

    • Peer Reviewed
  • [Journal Article] Stem cell factor contributes to tumorigenesis of mast cells via an autocrine/paracrine mechanism2013

    • Author(s)
      Amagai Y, Tanaka A, Matsuda A, Jung K, Ohmori K, Matsuda H
    • Journal Title

      J. Leukoc. Biol

      Volume: 93(2) Pages: 245-250

    • DOI

      DOI:10.1189/jlb.0512245.

    • Peer Reviewed
  • [Journal Article] Circadian rhythms and the effect of glucocorticoids on expression of the clock gene period1 in canine peripheral blood mononuclear cells2012

    • Author(s)
      Ohmori K, Nishikawa S, Oku K, Oida K, Amagai Y, Kajiwara N, Jung K, Matsuda A, Tanaka A, Matsuda H
    • Journal Title

      Vet. J

      Volume: S1090-0233(12) Pages: 00432-00437

    • DOI

      DOI:10.1016/j.tvjl.2012.10.010.

    • Peer Reviewed
  • [Journal Article] Supplementation of the fermented soy product ImmuBalance^IM effectively reduces itching behavior of atopic NC/Tnd mice2012

    • Author(s)
      Matsuda A, Tanaka A, Pan W, Okamoto N, Oida K, Kingyo N, Amagai Y, Xia Y, Jang H, Nishikawa S, Kajiwara N, Ahn G, Ohmori K, Matsuda H
    • Journal Title

      J. Dermatol. Sci

      Volume: 67(2) Pages: 130-139

    • DOI

      DOI:10.1016/j.jdermsci.2012.05.011.

    • Peer Reviewed
  • [Journal Article] Mast cells function as an alternative modulator of adipogenesis through 15-deoxy-delta-12,14-prostaglandin J22011

    • Author(s)
      Tanaka A, Nomura Y, Matsuda A, Ohmori K, Matsuda H
    • Journal Title

      Am. J. Physiol. Cell Physiol

      Volume: 301(6) Pages: C1360-1367

    • DOI

      DOI:10.1152/ajpcell.00514.2010.

    • Peer Reviewed
  • [Journal Article] Silencing of Int6 gene restores function of the ischemic hindlimb in a rat model for peripheral arterial disease2011

    • Author(s)
      Okamoto N, Tanaka A, Jung K, Karasawa K, Orito K, Matsuda A, Amagai Y, Oida K, Ohmori K, Matsuda H
    • Journal Title

      Cardiovasc. Res

      Volume: 92(2) Pages: 209-217

    • DOI

      DOI:10.1093/cvr/cvr203.

    • Peer Reviewed
  • [Journal Article] Peroxisome proliferator-activated receptor γ-mediated suppression of dendritic cell function prevents the onset of atopic dermatitis in NC/Tnd mice2011

    • Author(s)
      Jung K, Tanaka A, Fujita H, Matsuda A, Oida K, Karasawa K, Okamoto N, Ohmori K, Jee Y, Shin T, Matsuda H
    • Journal Title

      J. Allergy Clin. Immunol

      Volume: 127(2) Pages: 420-429

    • DOI

      DOI:10.1016/j.jaci.2010.10.043.

    • Peer Reviewed
  • [Journal Article] Glucocorticoid sensitivity depends on expression levels of glucocorticoid receptors in canine neoplastic mast cells2011

    • Author(s)
      Matsuda A, Tanaka A, Amagai Y, Ohmori K, Nishikawa S, Xia Y, Karasawa K, Okamoto N, Oida K, Jang H, Matsuda H
    • Journal Title

      Vet. Immunol. Immunopathol

      Volume: 144(3-4) Pages: 321-328

    • DOI

      DOI:10.1016/j.vetimm.2011.08.013.

    • Peer Reviewed
  • [Journal Article] Retinal Degeneration and rd1 Mutation in NC/Tnd Mice-A Human Atopic Dermatitis Model2011

    • Author(s)
      Karasawa K, Tanaka A, Jung K, Matsuda A, Okamoto N, Oida K, Ebihara N, Ohmori K, Matsuda H
    • Journal Title

      Curr. Eye Res

      Volume: 36 Pages: 350-357

    • DOI

      DOI:10.3109/02713683.2010.542268.

    • Peer Reviewed
  • [Journal Article] Patterns of aquaporin expression in the canine eye2011

    • Author(s)
      Karasawa K, Tanaka A, Jung K, Matsuda A, Okamoto N, Oida K, Ohmori K, Matsuda H
    • Journal Title

      Vet. J

      Volume: 190(2) Pages: e72-77

    • DOI

      DOI:10.1016/j.tvjl.2010.12.027.

    • Peer Reviewed
  • [Presentation] プロバイオティクスの経口投与が背井場の腸内環境に与える影響2012

    • Author(s)
      石坂さおり
    • Organizer
      第25回日本ウマ科学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2012-12-04
  • [Presentation] 蹄葉炎新規治療薬としてのNF-κB阻害剤の効果解析2012

    • Author(s)
      松田彬
    • Organizer
      第25回日本ウマ科学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2012-12-03
  • [Presentation] Involvement of daily metallic soap in skin conditions of patients with atopic dermatitis2012

    • Author(s)
      Tanaka A
    • Organizer
      Skin Allergy Meeting
    • Place of Presentation
      Berlin, Germany.
    • Year and Date
      2012-11-30
  • [Presentation] 金属石鹸がアトピー性皮膚炎自然発症モデルNC/Tndマウスの皮膚症状に及ぼす影響2012

    • Author(s)
      松田彬
    • Organizer
      第154回日本獣医学会学術集会
    • Place of Presentation
      盛岡
    • Year and Date
      2012-09-16
  • [Presentation] イヌ末梢血単核球における時計遺伝子の概日リズム解析2012

    • Author(s)
      大森啓太郎
    • Organizer
      第154回日本獣医学会学術集会
    • Place of Presentation
      盛岡
    • Year and Date
      2012-09-16
  • [Presentation] 海藻の一種であるカジメに含まれるdieckolの肥満細胞に対する効果2012

    • Author(s)
      Ahn Ginnae
    • Organizer
      第154回日本獣医学会学術集会
    • Place of Presentation
      盛岡
    • Year and Date
      2012-09-16
  • [Presentation] イヌ肥満細胞腫におけるc-kitmRNA全長の塩基配列解析2012

    • Author(s)
      北村亮
    • Organizer
      第154回日本獣医学会学術集会
    • Place of Presentation
      盛岡
    • Year and Date
      2012-09-16
  • [Presentation] 角膜損傷における水チャンネル・アクアポリンの発現変化2012

    • Author(s)
      Jung Kyungsook
    • Organizer
      第154回日本獣医学会学術集会
    • Place of Presentation
      盛岡
    • Year and Date
      2012-09-16
  • [Presentation] ラジオ波を用いた癌温熱療法の効果についての分子生物学的検討2012

    • Author(s)
      西川翔
    • Organizer
      第154回日本獣医学会学術集会
    • Place of Presentation
      盛岡
    • Year and Date
      2012-09-15
  • [Presentation] イヌ肥満細胞腫における幹細胞因子自己産生メカニズム2012

    • Author(s)
      雨貝陽介
    • Organizer
      第154回日本獣医学会学術集会
    • Place of Presentation
      盛岡
    • Year and Date
      2012-09-15
  • [Presentation] アトピー性皮膚炎モデルマウスにおける皮膚pHと皮膚バリア損傷の関連性2012

    • Author(s)
      Jang hyosun
    • Organizer
      第154回日本獣医学会学術集会
    • Place of Presentation
      盛岡
    • Year and Date
      2012-09-14
  • [Presentation] アトピー性皮膚炎に対する知覚神経刺激への反応性とTRPV1の関連性の検討2012

    • Author(s)
      Xia Yan
    • Organizer
      第154回日本獣医学会学術集会
    • Place of Presentation
      盛岡
    • Year and Date
      2012-09-14
  • [Presentation] リンパ球のグルココルチコイド 感受性におけるスプライシング制御因子 の役割2012

    • Author(s)
      松田彬
    • Organizer
      Conference for BioSignal and Medicine 2012
    • Place of Presentation
      志摩
    • Year and Date
      2012-09-01
  • [Presentation] イヌ肥満細胞腫におけるグルココルチコイド感受性に関する検討2011

    • Author(s)
      松田彬
    • Organizer
      第152回日本獣医学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2011-09-19
  • [Presentation] 樹状細胞の機能に対する核レセプターPPARγの役割2011

    • Author(s)
      田中あかね
    • Organizer
      第152回日本獣医学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2011-09-19
  • [Presentation] プロバイオティクスの経口投与が成馬の腸内環境に与える効果2011

    • Author(s)
      石坂さおり
    • Organizer
      第152回日本獣医学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2011-09-19
  • [Presentation] 知覚神経刺激に対するアトピー性皮膚炎自然発症モデルNC/Tndマウスの反応性の検討2011

    • Author(s)
      Xia Yan
    • Organizer
      第152回日本獣医学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2011-09-19
  • [Remarks]

    • URL

      http://www.tuat.ac.jp/~mol_path/index.html

  • [Patent(Industrial Property Rights)] オリゴヌクレオチド2011

    • Inventor(s)
      田中あかね、松田浩珍、松田彬
    • Industrial Property Rights Holder
      国立大学法人東京農工大学
    • Industrial Property Number
      特許、特願2011-274897
    • Filing Date
      2011-12-15

URL: 

Published: 2014-08-29  

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