2012 Fiscal Year Final Research Report
Design and Synthesis of Novel Immunostimulatory Molecules Based on α-Galactosyl Ceramides
| Project/Area Number |
23880011
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Bioproduction chemistry/Bioorganic chemistry
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| Research Institution | Gifu University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 糖脂質 |
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| Research Abstract |
Novel immunostimulators based on α-galactosyl ceramides were designed and synthesized by using a unique synthetic method developed by our group. Synthesis of α-galactoside/galactosaminide as a key structure was efficiently accomplished by DTBS-directed α-galactosylation developed by us. Fully protected framework of a target molecule was synthesized successfully. Unfortunately, however, poor soluble property of the target molecule produced after deprotection obliged us to redesign the structure of target molecules. We are currently trying to synthesize the redesigned molecule that is shortened the length of fatty acid in the ceramide moiety.
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