2012 Fiscal Year Final Research Report
Methodology development for acquisition of a numerous number of new natural products from filamentous
| Project/Area Number |
23880025
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied microbiology
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| Research Institution | University of Shizuoka |
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Principal Investigator |
NAKAZAWA Takehito 静岡県立大学, 大学院・薬学研究科, 客員共同研究員 (80608141)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 糸状菌 / 酵母 / 生合成 / 異種発現 |
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| Research Abstract |
A number of biosynthetic genes for fungal secondary metabolites were successfully reconstructed in yeast cells, and I successfully obtained natural products biosynthesized by them through heterologous production in yeast. I also developed molecular genetics systems for biosynthetic studies in some filamentous fungi. And I obtained a number of natural products, some of which are new/novel, through disruptions of genes involved in regulation of biosynthetic genes. I then found that several secondary metabolites are involved in regulation of transcription and sexual development (formation of sexual spores) in Chaetomium globosum.
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Research Products
(18 results)
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[Journal Article] Establishing a new methodology for genome mining and biosynthesis of polyketides and peptides through yeast molecular genetics.2012
Author(s)
K. Ishiuchi, T. Nakazawa, T. Ookuma, S. Sugimoto, M. Sato, Y. Tsunematsu, N. Ishikawa, H. Noguchi, K. Hotta, H. Moriya, K. Watanabe
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Journal Title
ChemBioChem
Volume: 13
Pages: 846-854
DOI
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[Presentation] Biosynthesis of Natural Products Through a Fungal Molecular Genetics.2012
Author(s)
T. Nakazawa, T. Ookuma, S. Sugimoto, S. Ichinoseki, Y. Gotanda, N. Ishikawa, Y. Tsunematsu, K. Ishiuchi, H. Noguchi, K. Watanabe
Organizer
11th European Conference on Fungal Genetics
Place of Presentation
Philipps-Universitat Marburg, Germany
Year and Date
20120330-0402
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