2012 Fiscal Year Final Research Report
Clarification of innate immune system in multiple sclerosis
| Project/Area Number |
23890005
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SASAKI Hidenao 北海道大学, 大学院・医学研究科, 教授 (80281806)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 神経免疫 / 多発性硬化症 / 自然免疫 |
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| Research Abstract |
We aimed to examine the impact of IFN-α, which is an important adjuvant in the innate immune system, on the adaptive immune system in Multiple Sclerosis (MS). There results suggest that CpG DNA-induced decreased IFN-α production causes pro-inflammatory cytokine secretion, and either IFN-α or IFN-ss induces anti-inflammatory cytokine secretion in the adaptive immune system in MS.
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