2012 Fiscal Year Final Research Report
Sialic acid binding immunoglobulin like lectin regulates osteoclast differentiation and function in destructive bone diseases
| Project/Area Number |
23890008
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 破骨細胞 / シグレック 15 / 細胞骨格 / 骨吸収 / 細胞融合 / 糖鎖 / 免疫グロブリン様受容体 |
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| Research Abstract |
Using genetically modified mice lacking Siglec-15 gene, we show that Siglec-15 regulates osteoclast development and bone resorption by modulating receptor activator of nuclear factor κB ligand (RANKL) signaling, in association with DNAX-activating protein 12kDa (DAP12), an adaptor protein bearing an immunoreceptor tyrosine-based activation motif (ITAM).
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