2012 Fiscal Year Final Research Report
Failure of ARE-nRNA control causes oncogenesis of oral cancer
| Project/Area Number |
23890010
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
KUROSHIMA Takeshi 北海道大学, 大学院・歯学研究科, 専門研究員 (00610669)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 口腔がん / ARE-mRNA / pp32 / pp32r1 / HuR |
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| Research Abstract |
In this study, we examined the mechanism of the export and stabilization of ARE-mRNA in oral cancer cells. We explored the role of pp32r1, a member of the pp32 family that has oncogenic properties, in the decay of HuR. HuR-pp32r1 complex was exported to the cytoplasm and the caspase-mediated decay of HuR was inhibited by pp32r1. We suggest that this function contributes to the oncogenic activity of pp32r1.
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