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2012 Fiscal Year Final Research Report

In vivo analysis of novel type of adult human pluripotent stem cells.

Research Project

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Project/Area Number 23890015
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field General anatomy (including Histology/Embryology)
Research InstitutionTohoku University

Principal Investigator

KURODA Yasumasa  東北大学, 大学院・医学系研究科, 助教 (00614504)

Project Period (FY) 2011 – 2012
Keywords多能性幹細胞 / 体性幹細胞 / 再生医療
Research Abstract

In this study, We tried to identify gene markers for isolating novel type of adult human pluripotent stem cells, Muse cells. Finally we were able to get some candidate from results of the next generation sequencing and the microarray analysis.

  • Research Products

    (15 results)

All 2013 2012 2011 Other

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (4 results) Remarks (1 results)

  • [Journal Article] Autologous mesenchymal stem cell-derived dopaminergic neurons function in parkinsonian macaques2013

    • Author(s)
      Hayashi T, Wakao S, Kitada M, Ose T, Watabe H, Kuroda Y, Mitsunaga K, Matsuse D, Shigemoto T, Ito A, Ikeda H, Fukuyama H, Onoe H, Tabata Y, Dezawa M.
    • Journal Title

      J. Clin. Invest

      Volume: 123(1) Pages: 272-84

    • DOI

      doi:10.1172/JCI62516

    • Peer Reviewed
  • [Journal Article] Transplantation of bone marrow stromal cells-derived neural precursor cells ameliorates deficits in a rat model of complete spinal cord transection2012

    • Author(s)
      Aizawa-Kohama M, Endo T, Kitada M, Wakao S, Sumiyoshi A, Matsuse D, Kuroda Y, Morita T, Riera JJ, Kawashima R, Tominaga T, Dezawa M.
    • Journal Title

      Cell Transplant

    • DOI

      doi:10.3727/096368912X658791

    • Peer Reviewed
  • [Journal Article] Morphologic and gene expression criteria for identifying human induced pluripotent stem cells2012

    • Author(s)
      Wakao S, Kitada M, Kuroda Y, Ogura F, Murakami T, Dezawa M.
    • Journal Title

      PLoS One

      Volume: 7(12) Pages: e48677

    • DOI

      doi:10.1371/journal.pone.0048677

    • Peer Reviewed
  • [Journal Article] Isolation of adult human pluripotent stem cells from mesenchymal cell populations and their application to liver damages2012

    • Author(s)
      Wakao S, Kitada M, Kuroda Y, Dezawa M.
    • Journal Title

      Methods Mol. Biol

      Volume: 826 Pages: 89-102

    • DOI

      doi:10.1007/978-1-61779-468-1_8

    • Peer Reviewed
  • [Journal Article] Multilineage-differentiating stress-enduring (Muse) cells are a primary source of induced pluripotent stem cells in human fibroblasts2011

    • Author(s)
      Wakao S, Kitada M, Kuroda Y, Shigemoto T, Matsuse D, Akashi H, Tanimura Y, Tsuchiyama K, Kikuchi T, Goda M, Nakahata T, Fujiyoshi Y, Dezawa M.
    • Journal Title

      Proc. Natl. Acad. Sci. U.S.A.

      Volume: 108(24) Pages: 9875-80

    • DOI

      doi:10.1073/pnas.1100816108

    • Peer Reviewed
  • [Journal Article] Lectins as a tool for detecting neural stem/progenitor cells in the adult mouse brain2011

    • Author(s)
      Kitada M, Kuroda Y, Dezawa M.
    • Journal Title

      Anat. Rec

      Volume: 294(2) Pages: 305-21

    • DOI

      doi:10.1002/ar.21311

    • Peer Reviewed
  • [Journal Article] Mesenchymal stem cells and umbilical cord as sources for Schwann cell differentiation: their potential in peripheral nerve repair2011

    • Author(s)
      Kuroda Y, Kitada M, Wakao S, Dezawa M.
    • Journal Title

      The Open Tissue Engineering and Regenerativemedicine Journal

      Volume: 4 Pages: 54-63

    • DOI

      doi:10.2174/1875043501104010054

    • Peer Reviewed
  • [Journal Article] Bone Marrow Mesenchymal Cells: How Do They Contribute to Tissue Repair and Are They Really Stem Cells?2011

    • Author(s)
      Kuroda Y, Kitada M, Wakao S, Dezawa M.
    • Journal Title

      Arch. Immunol. Ther. Exp

      Volume: 59 Pages: 369-78

    • DOI

      doi:10.1007/s00005-011-0139-9

    • Peer Reviewed
  • [Journal Article] 間葉系幹細胞における多様な分化と組織修復能を担うMuse細胞の発見2011

    • Author(s)
      黒田康勝、出澤真理
    • Journal Title

      血液フロンティア

      Volume: 21(11) Pages: 1664-1669

    • Peer Reviewed
  • [Journal Article] 間葉系幹細胞の特性と再生医療における展開2011

    • Author(s)
      黒田康勝、出澤真理
    • Journal Title

      再生医療

      Volume: 10(1) Pages: 8-11

    • Peer Reviewed
  • [Presentation] 他家移植へ向けたMuse細胞の可能性2013

    • Author(s)
      黒田康勝、繁本妙子、出澤真理
    • Organizer
      第118回日本解剖学会総会・全国学術集会
    • Place of Presentation
      香川
    • Year and Date
      20130328-20130330
  • [Presentation] 他家移植へ向けたMuse細胞の可能性2012

    • Author(s)
      黒田康勝、繁本妙子、出澤真理
    • Organizer
      解剖学会第58回東北・北海道連合支部学術集会
    • Place of Presentation
      山形
    • Year and Date
      20120922-20120923
  • [Presentation] 成人ヒト間葉系細胞に内在する多分化能細胞の探索2012

    • Author(s)
      黒田康勝, (他9名)
    • Organizer
      第11回日本再生医療学会総会
    • Place of Presentation
      横浜
    • Year and Date
      20120612-20120614
  • [Presentation] Novel type of adult human pluripotent stem cells that exist in mesenchymal cell population2012

    • Author(s)
      Yasumasa Kuroda, (他9名)
    • Organizer
      The 5th Pan Pacific Symposium on Stem Cells and (他9名)Cancer Research
    • Place of Presentation
      台湾 (中華人民共和国)
    • Year and Date
      20120413-20120415
  • [Remarks] 東北大学大学院医学系研究科細胞組織学分野・人体構造学分野

    • URL

      http://www.stemcells.med.tohoku.ac.jp/index.html

URL: 

Published: 2014-08-29  

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