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2012 Fiscal Year Final Research Report

The analysis of molecular mechanisms of the inflammatory macrophage migration by using a small molecule inhibitor to plasminogen activator inhibitor 1.

Research Project

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Project/Area Number 23890019
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Endocrinology
Research InstitutionTohoku University

Principal Investigator

ICHIMURA Atsuhiko  東北大学, 大学院・医学系研究科, 助教 (10609209)

Project Period (FY) 2011 – 2012
Keywords薬理学 / 免疫学 / 炎症 / マクロファージ / PAI-1
Research Abstract

Our findings demonstrated that a small molecule PAI-1 inhibitor represents a novel class of anti-inflammatory agents targeting MФ migration by the inhibition of the interaction of PAI-1 with low-density lipoprotein receptor-related protein.

  • Research Products

    (6 results)

All 2013 2012 2011

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (2 results)

  • [Journal Article] A small molecule inhibitor to plasminogen activator inhibitor 1 inhibits macrophage migration2013

    • Author(s)
      Ichimura A, Matsumoto S, Suzuki S, Dan T, Yamaki S, Sato Y, Kiyomoto H, Ishii N, Okada K, Matsuo O, Hou FF, Vaughan DE, van Ypersele de Strihou C, Miyata T.
    • Journal Title

      Arterioscler Thromb Vasc Biol.

      Volume: Epub ahead of print

    • DOI

      doi:10.1161/ATVBAHA.113.301224.

    • Peer Reviewed
  • [Journal Article] Physiological functions of fatty acid receptors andtheir therapeutic potential2012

    • Author(s)
      Hara T, Hirasawa A, Ichimura A, Kimura I, Tsujimoto G.
    • Journal Title

      Nihon Yakurigaku Zasshi

      Volume: 140 Pages: 275-279

    • URL

      https://www.jstage.jst.go.jp/article/fpj/140/6/140_275/_article 査読有り

    • Peer Reviewed
  • [Journal Article] Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human2012

    • Author(s)
      Ichimura A, Hirasawa A, Poulain-Godefroy O, Bonnefond A, Hara T, Yengo L, Kimura I, Leloire A, Liu N, Iida K, Choquet H, Besnard P, Lecoeur C, Vivequin S, Ayukawa K, Takeuchi M, Ozawa K, Tauber M, Maffeis C, Morandi A, Buzzetti R, Elliott P, Pouta A, Jarvelin MR, Korner A, Kiess W, Pigeyre M, Caiazzo R, Van Hul W, Van Gaal L, Horber F, Balkau B, Levy-Marchal C, Rouskas K, Kouvatsi A, Hebebrand J,Hinney A, Scherag A, Pattou F, Meyre D, Koshimizu TA, Wolowczuk I, Tsujimoto G, Froguel P.
    • Journal Title

      Nature

      Volume: 483 Pages: 350-42012

    • DOI

      doi:10.1038/nature10798.

    • Peer Reviewed
  • [Journal Article] Early treatment with olmesartan prevents juxtamedullary glomerular podocyte injury and the onset of microalbuminuria in type 2 diabeticrats2012

    • Author(s)
      Sofue T, Kiyomoto H, Kobori H, Urushihara M, Nishijima Y, Kaifu K, Hara T, Matsumoto S, Ichimura A, Ohsaki H, Hitomi H, Kawachi H, Hayden MR, Whaley-Connell A, Sowers JR, Ito S, Kohno M, Nishiyama A.
    • Journal Title

      Am J Hypertens

      Volume: 25 Pages: 604-611

    • DOI

      doi:10.1038/ajh.2012.1.

    • Peer Reviewed
  • [Presentation] International Symposium on the Maillard Reaction2012

    • Author(s)
      Atsuhiko Ichimura, Takashi Dan, Tadayuki Tsujita, Miyata Toshio
    • Organizer
      Generation of Glyoxalase 1-deficient mice 11^<th>
    • Place of Presentation
      Nacy France
    • Year and Date
      2012-09-18
  • [Presentation] グリオキサラーゼ1欠損マウスの創出2011

    • Author(s)
      市村敦彦、段孝、宮田敏男
    • Organizer
      第21回日本メイラード学会
    • Place of Presentation
      東京ステーションコンファレンス602,東京
    • Year and Date
      2011-10-28

URL: 

Published: 2014-08-29  

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