2012 Fiscal Year Final Research Report
Induction of ameloblasts in high efficiency from induced pluripotent stem cells
| Project/Area Number |
23890022
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
ARAKAKI Makiko 東北大学, 大学院・歯学研究科, 助教 (80610675)
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| Project Period (FY) |
2011 – 2012
|
| Keywords | iPS細胞 / エナメル芽細胞 / 歯 / 再生 / 歯原性上皮細胞 |
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| Research Abstract |
iPS cells are capable to be induced to ameloblasts when iPS cells were cultured with ameloblastin (Ambn) high expression dental epithelial cell line SF2-24, or cultured in the presence of conditioned medium (CM) of SF2-24 culture supernatant. Additionally, it is indicated that soluble factors such as Ambn, NT-4 and BMP, secreted from SF2 cells to culture medium, perform an important role for differentiation iPS cellsinto ameloblasts.
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Research Products
(4 results)
