2012 Fiscal Year Final Research Report
Development of the controlled release- medicine for pain treatment using drug delivery system.
| Project/Area Number |
23890027
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Gunma University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | ドラッグデリバリーシステム / 徐放薬 / 鼻粘膜 / 臨床試験 / リドカイン |
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| Research Abstract |
The controlled release- lidocaine sheet significantly raised mean pain thresholds in a nasal mucous membrane compared with that of preadministration more than 72 hours. Feeling a pain by some pressure stimulation suggested that lidocaine of the component could not reach subcutaneous tissue, but only an outer layer of a mucous membrane. As for side effects, almost all had reactive serous rhinorrhea, but obvious serious adverse events such as a liver injury, a renal injury, pancytopenia and the other were not observed. It may be possible to lead a single administration of the controlled release- lidocaine sheet to the simple and effective postoperative analgesia with few side effects in future.
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