Role of CD69 for the generation of memory T helper lymphocytes

2012 Fiscal Year Final Research Report

• Project/Area Number: 23890030
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Immunology
• Research Institution: Chiba University
• Principal Investigator: SHINODA Kenta 千葉大学, 大学院・医学研究院, 特任助教 (10612195)
• Project Period (FY): 2011 – 2012
• Keywords: アレルギー・喘息 / 免疫学

Research Abstract

Memory T helper (Th) lymphocytes play an essential role in immunologicalmemory. However, little is known about the molecular mechanisms of the generation and maintenanceof memory Th cells. We focused on CD69 and examined to clarify the role of CD69 in memory Th cells.Although CD69 does not appear to be required for the development of effector Th cells, the number ofantigen-specific memory Th cells in CD69-deficient mice dramatically decreased compared to wild-typemice. CD69 plays a crucial role in the generation of memory Th cells and that the relocation of effectorTh cells to the BM is essential for generation of memory Th cells .

Research Products

• [Journal Article] Regulation ofmemory CD4 T-cell pool size and function bynatural killer T cells in vivo (2012)
  • Author(s): Iwamura, C., Shinoda, K., Endo, Y., Watanabe, Y., Tumes, J. D., Motohashi, S., Kawahara, K.,Kinjo, Y., and Nakayama, T.
  • Journal Title: Proc. Natl. Acad.Sci. USA Volume: 109(42) Pages: 16992-16997
  • DOI: DOI:10.1073/pnas.1203494109
  • Peer Reviewed
• [Journal Article] The transcription factor Sox4 is a downstreamtarget of signaling by the cytokine TGF-b andsuppresses T_H2 differentiation (2012)
  • Author(s): Kuwahara, M., Yamashita, M., Shinoda, K.,Tofukuji, S., Onodera, A., Shinnakasu, R.,Motohashi, S., Hosokawa, H., Tumes, D.,Iwamura, C., Lefebvre, V., and Nakayama, T.
  • Journal Title: Nat. Immunol Volume: 13(8) Pages: 778-786
  • DOI: DOI:10.1038/ni.2362
  • Peer Reviewed
• [Journal Article] Type IImembrane protein CD69 regulates theformation of resting T-helper memory (2012)
  • Author(s): Shinoda, K., Tokoyoda, K., Hanazawa, A.,Hayashizaki, K., Zehentmeier, S., Hosokawa,H., Iwamura, C., Koseki, H., Tumes, J. D., Radbruch, A., and Nakayama, T.
  • Journal Title: Proc.Natl. Acad. Sci. USA Volume: 109(19) Pages: 7409-7414
  • DOI: DOI:10.1073/pnas.1118539109
  • Peer Reviewed
• [Journal Article] MurineSchnurri-2 controls Natural Killer cellfunction and lymphoma development (2011)
  • Author(s): Yamashita, J., Iwamura, C., Mitsumori, K.,Hosokawa, H., Sasaki, T., Takahashi, M.,Tanaka, H., Kaneko, K., Hanazawa, A.,Watanabe, Y., Shinoda, K., Tumes, D.,Motohashi, S., and Nakayama, T.
  • Journal Title: Leuk.Lymphoma Volume: 53(3) Pages: 479-86
  • DOI: DOI:10.3109/10428194.2011.625099
  • Peer Reviewed
• [Journal Article] Repressor of GATA negatively regulatesmurine contact hypersensitivity through theinhibition of type-2 allergic responses (2011)
  • Author(s): Hirasaki, Y., Iwamura, C., Yamashita, M.,Ito, T., Kitajima, M., Shinoda, K., Namiki,T., Terasawa, K., and Nakayama, T.
  • Journal Title: Clin. Immunol Volume: 139 Pages: 267-276
  • DOI: DOI:10.1016/j.clim.2010.12.022
  • Peer Reviewed
• [Presentation] Toshinori Nakayama Generationand Maintenance of memory T-helperlymphocytes (2013)
  • Author(s): Kenta Shinoda, Chiaki Iwamura, Koji Tokoyoda
  • Organizer: The 1^<st> Symposium ofInternational Immunological Memory and Vaccine Forum (IIMVF)
  • Year and Date: 2013-01-29
• [Presentation] CD69 regulates the formation of resting T-helper memory (2012)
  • Author(s): Shinoda, K., Tokoyoda, K., Hanazawa, A., Hayashizaki, K., Hosokawa, H., Iwamura, C., Koseki, H., Tumes, D., Radbruch, A., andNakayama, T.
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸
  • Year and Date: 20121205-07
• [Presentation] CD69regulates the formation of resting T-helpermemory (2012)
  • Author(s): Shinoda, K., Tokoyoda, K., Hanazawa, A.,Hayashizaki, K., and Nakayama, T.
  • Organizer: THE 34th NAITO CONFERENCEON Infection, Immunity, and their control forHealth
  • Place of Presentation: Sapporo
  • Year and Date: 20121016-19
• [Presentation] Generation and maintenance ofmemory CD4 T cells. (招待講演) (2012)
  • Author(s): Nakayama, T., Endo, Y., Kuwahara, M.,Yamashita, M., Iwamura, C., Shinoda, K., andTokoyoda, K.
  • Organizer: THE 34thNAITO CONFERENCE ON Infection,Immunity, and their control for Health
  • Place of Presentation: Sapporo
  • Year and Date: 20121016-19
• [Presentation] CD69は記憶ヘルパーT細胞の形成を制御する (2012)
  • Author(s): 篠田健太、常世田好司、花澤麻美、林崎浩史、中山俊憲
  • Organizer: 第22回Kyoto T Cell Conference
  • Place of Presentation: 和順会館
  • Year and Date: 20120706-07
• [Presentation] CD69 regulates theformation of resting T helper memory (2012)
  • Author(s): Shinoda K., Nakayama T
  • Organizer: 14th International Conference on Lymphocyte Activation and Immune Regulation
  • Place of Presentation: NewPort Beach, USA
  • Year and Date: 20120203-05
• [Presentation] 活性化NKT細胞によるメモリーTh2 細胞の増加と機能変化/ Selective expansion andfunctional modulation of memory Th2 cells byactivated NKT cells in vivo (2011)
  • Author(s): 岩村千秋、篠田健太、高橋克己、中山俊憲
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 20111127-29
• [Presentation] 骨髄における T ヘルパ-記憶の成立/Establishment of T helper memory in bonemarrow (2011)
  • Author(s): Tokoyoda, K., Shinoda, K., Hanazawa, A.,Hayashizaki, K., Radbruch, A., and Nakayama,T.
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 20111127-29
• [Presentation] ROGはTh2による肥満細胞の脱顆粒を制御する事で接触性皮膚炎を抑制する/Repressor of GATA negatively regulates the induction of contacthypersensitivity via Th2-induced mast cell degranulation (2011)
  • Author(s): Hirasaki, Y., Iwamura, C., Yamashita, M., Ito, T.,Shinoda, K., and Nakayama, T.
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 20111127-29
• [Presentation] Sox4 は TGFbにより誘導され、Th2型免疫反応を抑制する/Sox4 acts as a downstream target of TGFb and suppresses Th2 type immune responses (2011)
  • Author(s): Kuwahara, M., Iwamura, C., Shinoda, K.,Tofukuji, S., Suzuki, J., Nakayama, T., andYamashita, M.
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 20111127-29
• [Presentation] Selective expansion and functional modulation of memory Th2 cells by activated NKT cells in vivo (2011)
  • Author(s): 岩村千秋、篠田健太、花澤麻美、中山俊憲
  • Organizer: 第21回 Kyoto T Cell Conference
  • Place of Presentation: 京都
  • Year and Date: 20110610-11
• [Presentation] HMGbox型転写因子Sox4はTGF-b刺激で誘導され、Th2細胞分化を抑制する (2011)
  • Author(s): 桑原誠、岩村千秋、篠田健太、東福寺聡一、鈴木淳平、中山俊憲、山下政克
  • Organizer: 第21回Kyoto T CellConference
  • Place of Presentation: 京都
  • Year and Date: 20110610-11
• [Book] 記憶ヘルパーT細胞形成におけるCD69の役割 (2012)
  • Author(s): 篠田健太、中山俊憲
  • Total Pages: 243(3):246-247
  • Publisher: 医学のあゆみ