2012 Fiscal Year Final Research Report
Analysis of intracellular trafficking of membrane proteins of Nipah virus
| Project/Area Number |
23890038
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Virology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | ニパウイルス / 膜タンパク質 / 細胞内局在 |
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| Research Abstract |
To understand intracellular trafficking of membrane glycoprotein (G) of nipah virus, intracellular localization of G expressed in cultured cells was analyzed. G localized in endoplasmic reticulum (ER) and golgi apparatus, suggesting that G is transported through the regular intracellular trafficking pathway of membrane proteins of the hosts. Deletion mutant analysis further suggested that outer membrane region contributes to the transport of G from ER to golgi apparatus. These findings are important clues to understand the intracellular trafficking of the nipah virusmembrane protein.
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