2012 Fiscal Year Final Research Report
Development of p53 expressing viral vector using human insulator.
| Project/Area Number |
23890046
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MORI Mayuyo 東京大学, 医学部付属病院, 登録研究医 (30570452)
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| Project Period (FY) |
2011 – 2012
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| Keywords | p53・インスレーター |
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| Research Abstract |
Efficient and continuous expression of a therapeutic transgene is a key factor for improving the efficacy of gene therapy. Some insulators are known to contribute to continuous high-level expression of a therapeutic transgene. In this study, we modified an adeno-associated virus serotype 2 (AAV2) vector expressing p53 from the mouse muscle creatine kinase gene promoter-enhancer (Ckm).
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