2012 Fiscal Year Final Research Report

Elucidation of the mechanism of toxic metal and radiation-induced disease onset using stress signaling-deficient mice

Research Project

Project/Area Number	23890049
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Hygiene
Research Institution	Tokyo Medical and Dental University
Principal Investigator	IWATSUKI Mamiko 東京医科歯科大学, 難治疾患研究所, 特任助教 (10609689)
Project Period (FY)	2011 – 2012
Keywords	環境中有害物質 / 毒性金属 / ノックアウトマウス / ストレスシグナル / メチル水
Research Abstract	Mkk7flox/flox Synapsin-Cre mice were made and exposed with methyl mercury. To examine cell proliferation and apoptosis of brain neurons, we did Nissl stain, BrdU incorporation, TUNEL and active Caspase stains. Furthermore, we did cDNA microarrayof the knockout mice. We are now analyzing these results.

(2 results)