• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2012 Fiscal Year Final Research Report

Analysis of the role of Trxl and Txnip under the oxidative stress condition in periodontitis.

Research Project

  • PDF
Project/Area Number 23890058
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Periodontal dentistry
Research InstitutionTokyo Medical and Dental University

Principal Investigator

EBE Noriko  東京医科歯科大学, 歯周病学分野, 医員 (20611099)

Research Collaborator YOKOYAMA Miki  東京医科歯科大学, 大学院・医歯学総合研究科, 准教授 (70191533)
ISEKI Sachiko  東京医科歯科大学, 大学院・医歯学総合研, 教授 (80251544)
RAJAPAKSHE R.M.A.R  東京医科歯科大学, 大学院・医歯学総合研究科, 大学院生
IZUMI Yuichi  東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (60159803)
Project Period (FY) 2011 – 2012
Keywords歯周免疫機能学 / 酸化ストレス / TRX1(チオレドキシン 1) / Txnip(thioredoxin interacting protein) / ポケット上皮
Research Abstract

Oxidative stress exists in the periodontal pocket side with periodontal patients. We used TRX1 antibody as an oxidative marker. TRX1 was expressed in gingival epithelium, pocket epithelium and T cells under the periodontal pocket epithelium. Especially, TRX1 expression was increased in periodontal patients compared with healthy patients. In vitro study, we have used Ca9-22 cells (gingival epithelial cell line). Further study, it is necessary to use T cells. In the periodontal pocket side at acute inflammation, these oxidative tissues may be involved in the pathogenesis periodontal disease.

  • Research Products

    (3 results)

All 2012 2011 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (1 results) Book (1 results)

  • [Journal Article] Possible Translocation of Periodontal Pathogens into the Lymph Nodes Draining the Oral Cavity2012

    • Author(s)
      G. Amodini Rajakaruna, Makoto Umeda, Keisuke Uchida, Asuka Furukawa, Bae Yuan, Yoshimi Suzuki, Ebe Noriko, Yuichi Izumi, and Yoshinobu Eishi
    • Journal Title

      The Journal of Microbiology

      Volume: Vol.50,No.5 Pages: 827-836

    • DOI

      doi:10.1007/s12275-012-2030-8

    • Peer Reviewed
  • [Presentation] 酪酸による酸化ストレス誘導時に放出されるHMGB1の解析2011

    • Author(s)
      江部典子,横山三紀,寺澤和恵,柳下正樹,和泉雄一
    • Organizer
      第135回日本歯科保存学会2011年度秋季学術大会
    • Place of Presentation
      大阪,大阪国際交流センター
    • Year and Date
      2011-10-21
  • [Book] Studies on Gingivitis and Periodontal Disesase

    • Author(s)
      Noriko Ebe, Miki Hara-Yokoyama and Yuichi Izumi
    • Total Pages
      10
    • Publisher
      Springer Science and Business Media Plus

URL: 

Published: 2014-08-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi