2011 Fiscal Year Final Research Report
Functional analysis of synapse morphology regulated by MKL, an actin-binding coactivator
| Project/Area Number |
23890065
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | University of Toyama |
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Principal Investigator |
ISHIKAWA Mitsuru 富山大学, 大学院・医学薬学研究部(薬学), 助教 (10613995)
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| Project Period (FY) |
2011
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| Keywords | アクチン / SRF / 転写因子 / 樹状突起 / Rho |
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| Research Abstract |
In characterizing MKL1 transcripts expressed in rat brain, we have identified a novel transcript in addition to the other two transcripts. Functional comparison of these isoforms with regard to their ability to localize to the nucleus, drive SRE-mediated transcription and dendritic morphology revealed that one of the MKL1 isoforms is more active than the others in all these assays.
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