2012 Fiscal Year Final Research Report
Study of novel influx transporters at the blood-tissue barrier
| Project/Area Number |
23890066
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical pharmacy
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| Research Institution | University of Toyama |
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Principal Investigator |
KUBO Yoshiyuki 富山大学, 大学院・医学薬学研究部(薬学), 講師 (20377427)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 血液網膜関門 / トランスポーター / 薬物送達 / オーファン分子 |
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| Research Abstract |
In vivo and in vitro analyses were performed to study transport mechanisms for cationic drugs, such as [^3H]verapamil, at the blood-retinal barrier （BRB).The results obtained suggested the involvement of carrier-mediated transport system in the influx transport of cationic drugs across the inner BRB. Furthermore, orphan transporters were identified as candidate molecules responsible for drug transport at the inner BRB.
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