2012 Fiscal Year Final Research Report
Investigation of the angiogenesis role by BMP2 and development of new method of osteogenesis by BMP2 producing cells
| Project/Area Number |
23890071
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | BMP2 / 血管内皮細胞 |
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| Research Abstract |
We firstly showed that vascular endothelial cells and vascular smooth muscle cells produce BMP2 during distraction osteogenesis. During distraction osteogenesis, angiogenesis occurs at soft tissues around bone at first, which cells produce BMP2.It could promote bone regeneration. And it is showed that BMP2 from vascular cells and PIGF from soft tissue play an important role in bone formation.
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