2012 Fiscal Year Final Research Report
Early diagnosis with in vivo laser confocal microscopy incytomegalovirus corneal endotheliitis and Acanthamoeba keratitis
| Project/Area Number |
23890072
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | サイトメガロウイルス角膜内皮炎 / アカントアメーバ角膜炎 / レーザー共焦点顕微鏡 |
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| Research Abstract |
In this study, we performed in vivo laser confocal microscopic analysis in patients with cytomegalovirus corneal endotheliitis and Acanthamoebakeratitis. In cytomegalovirus corneal endotheliitis, a two-dimensional reconstruction map of the owl’s eye cells was created using acquired confocal images; the maps showed circular patterns. Also, we demonstrated that there is an association between owl’s eye cells observed by confocal microscopy and coin-shaped lesions observed by slit-lampbiomicroscopy. In patients with persistence of Acanthamoeba keratitis, invasion of cysts into Bowman’s layer was characteristically observed. This finding suggests that invasion of Acanthamoeba cysts into Bowman’s layer may be a useful predictor for a persistent clinical course.
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