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2012 Fiscal Year Final Research Report

Analysis and risk assessment of intestinal inflammation induced by food-containing nanoparticles.

Research Project

  • PDF
Project/Area Number 23890082
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Hygiene
Research InstitutionMie University

Principal Investigator

OIKAWA Saeko (TADA Saeko)  三重大学, 地域イノベーション学研究科, 特任助教 (90610585)

Project Period (FY) 2011 – 2012
Keywordsナノ粒子 / 二酸化チタン / 酸化亜鉛 / 炎症
Research Abstract

The present study investigated the cytotoxicity, production of reactive oxygen species (ROS) and inflammatory cytokine induced by nano-TiO2 and nano-ZnO particles using human monocytic leukemia cells (THP-1) and human colon cancer cells (Caco-2). The viability of THP-1 macrophages exposed to nano-ZnO was lower than that to nano-TiO2 THP-1. The production of ROS and IL-1βshowed a tendency to be increased by nano-TiO2 particles. This study indicated that nano-TiO2 particles may induce inflammation in THP-1 macrophages through production of ROS and IL-1β, and nano- ZnO particles were suggested to be more toxic to THP-1 macrophages than nano-TiO_2 .

  • Research Products

    (18 results)

All 2013 2012

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (16 results)

  • [Journal Article] Serial changes in adipocytokines and cardiac function in a rat model of the metabolic syndrome2013

    • Author(s)
      Yamaguchi T, Kitamori K, Ichihara G, Suzuki Y, Ochiai M, Yamada Y, Tada-Oikawa S, Tsuchikura S, Yamori Y, Ichihara S
    • Journal Title

      Clinical and Experimental Pharmacology and Physiology

      Volume: (印刷中)

    • Peer Reviewed
  • [Journal Article] Altered gene and protein expression in liver of the obese spontaneously hypertensive/NDmcr-cp rat2012

    • Author(s)
      Chang J, Oikawa S, Ichihara G, Nanpei Y, Hotta Y, Yamada Y, Tada-Oikawa S, Iwahashi H, Kitagawa E, Takeuchi I, Yuda M, Ichihara S
    • Journal Title

      Nutrition & Metabolism (Lond)

      Volume: 9巻1号 Pages: 87-97

    • DOI

      DOI:10.1186/1743-7075-9-87

    • Peer Reviewed
  • [Presentation] ナノ酸化亜鉛によるマクロファージの変性LDL取り込み作用への影響2013

    • Author(s)
      及川(多田)佐枝子、鈴木悠加、出岡淑、市原学、市原佐保子
    • Organizer
      第83回日本衛生学会学術総会
    • Place of Presentation
      金沢
    • Year and Date
      2013-03-25
  • [Presentation] ナノ酸化亜鉛による血管内皮障害への影響2013

    • Author(s)
      鈴木悠加、及川(多田)佐枝子、出岡淑、市原学、市原佐保子
    • Organizer
      第83回日本衛生学会学術総会
    • Place of Presentation
      金沢
    • Year and Date
      2013-03-25
  • [Presentation] ナノ酸化亜鉛が、ブレオマイシンによって誘導されるマウスの肺線維症に与える影響2013

    • Author(s)
      呉〓〓、市原学、及川(多田)佐枝子、鈴木悠加、常杰、橋本直純、長谷川好規、ガバザコリナ、ガバザエステバン、市原佐保子
    • Organizer
      第83回日本衛生学会学術総会
    • Place of Presentation
      金沢
    • Year and Date
      2013-03-25
  • [Presentation] Zinc oxide particles induced migration of monocytes and increased macrophage cholesterol uptake2013

    • Author(s)
      Yuka Suzuki, Saeko Tada-Oikawa, Gaku Ichihara, Sahoko Ichihara
    • Organizer
      52th Annual Meeting SOCIETY OF TOXICOLOGY
    • Place of Presentation
      San Antonio, USA
    • Year and Date
      2013-03-13
  • [Presentation] ナノ酸化亜鉛による単球遊走作用とマクロファージのコレステロール取り込み作用への影響2013

    • Author(s)
      鈴木悠加、及川(多田)佐枝子、出岡淑、市原学、市原佐保子
    • Organizer
      第12回分子予防環境医学研究会
    • Place of Presentation
      筑波
    • Year and Date
      2013-02-01
  • [Presentation] The effects of metal oxide nanoparticles on angiogenesis in transgenic zebrafish2013

    • Author(s)
      常杰、市原学、及川(多田)佐枝子、島田康人、田中利男、市原佐保子
    • Organizer
      第12回分子予防環境医学研究会
    • Place of Presentation
      筑波
    • Year and Date
      2013-02-01
  • [Presentation] Dispersion method for safety research on manufactured nanomaterials2012

    • Author(s)
      Wenting Wu, Gaku Ichihara, Yuka Suzuki, Kiyora Izuoka, Saeko Oikawa-Tada, Jie Chang, Kiyoshi Sakai, Kunichi Miyazawa, Dale Porter, Vincet Castranova, Masami Kawaguchi, Sahoko Ichihara
    • Organizer
      第40回産業中毒・生物学的モニタリング研究会
    • Place of Presentation
      東京
    • Year and Date
      2012-11-16
  • [Presentation] Cytotoxicity and inflammatory responses induced by nano-sized metal oxide nanoparticles in human monocytic leukemia cells2012

    • Author(s)
      Saeko Tada-Oikawa, Masayuki Yabata, Kiyora Izuoka, Jie Chang, Yuka Ota, Wenting Wu, Sahoko Ichihara, Gake Ichihara
    • Organizer
      International Congress on Safety of Engineered Nanoparticles and Nanotechnologies
    • Place of Presentation
      Helsinki, Finland
    • Year and Date
      2012-10-29
  • [Presentation] Dispersion Method for Safety Researches on Manufactured Nanomaterials2012

    • Author(s)
      Wenting Wu, Gaku Ichihara, Yuka Suzuki, Kiyora Izuoka, Saeko Oikawa-Tada, Jie Chang, Kiyoshi Sakai, Kunichi Miyazawa, Dale Porter, Vincet Castranova, Masami Kawaguchi, Sahoko Ichihara
    • Organizer
      International Union of Materials Research societies-International Union of Materials Research societies-International Conference on Electronic Materials 2012
    • Place of Presentation
      Yokohama
    • Year and Date
      2012-09-26
  • [Presentation] Cytotoxicity induced by nano-sized titanium dioxide in human monocytic leukemia cells (THP-1)2012

    • Author(s)
      Saeko Tada-Oikawa, Sahoko Ichihara,, Kiyora Izuoka,, Masayuki Yabata, Jie Chang, Yuka Ota, Wenting Wu, Gaku Ichihara
    • Organizer
      International Union of Materials Research societies-International Conference on Electronic Materials 2012
    • Place of Presentation
      Yokohama
    • Year and Date
      2012-09-24
  • [Presentation] Cytotoxicity and inflammatory responses induced by nano-sized metal oxide nanoparticles in human monocytic leukemia cells2012

    • Author(s)
      Sahoko Ichihara, Saeko Tada-Oikawa, Masayuki Yabata, Kiyora Izuoka, Jie Chang, Yuka Ota, Wenting Wu, Gaku Ichihara
    • Organizer
      The 6th International Conference on Nanotoxicology
    • Place of Presentation
      Beijing, China
    • Year and Date
      2012-09-05
  • [Presentation] Dispersion method for safety research on manufactured nanomaterials2012

    • Author(s)
      Wenting Wu, Gaku Ichihara, Yuka Suzuki, Kiyora Izuoka, Saeko Oikawa-Tada, Jie Chang, Kiyoshi Sakai, Kunichi Miyazawa, Dale Porter, Vincet Castranova, Masami Kawaguchi, Sahoko Ichihara
    • Organizer
      The 6th International Conference on Nanotoxicology
    • Place of Presentation
      Beijing, China
    • Year and Date
      2012-09-05
  • [Presentation] Dispersion method for in vivo safety reseaches on manufactured nanomaterials2012

    • Author(s)
      Wenting Wu, Sahoko Ichihara, Saeko Tada-Oikawa, Jie Chang, Gaku Ichihara
    • Organizer
      The 6th International Congress of Asia Society of Toxicology
    • Place of Presentation
      Sendai, Japan
    • Year and Date
      2012-07-20
  • [Presentation] Oxidative modification leads to the left ventricular dysfunction in cardiomyopathy2012

    • Author(s)
      Sahoko Ichihara, Jie Chang, Saeko Tada-Oikawa, Chisa Ando, Kentaro Kuzuya, Gaku Ichihara, Shinji Oikawa
    • Organizer
      The 49th Congress of the European Societies of Toxicology
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2012-06-19
  • [Presentation] 二酸化チタンナノ粒子による細胞毒性作用および炎症反応誘導作用の解析2012

    • Author(s)
      及川(多田)佐枝子、呉〓〓、市原学 、常杰 、矢端将行 、及川伸二、市原佐保子
    • Organizer
      第85回日本産業衛生学会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-05-31
  • [Presentation] 工業ナノマテリアル安全性研究のための分散法2012

    • Author(s)
      呉〓〓、市原佐保子、常杰、及川(多田)佐枝子、太田有香、矢端将行、市原学
    • Organizer
      第85回日本産業衛生学会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-05-31

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Published: 2014-08-29  

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