2012 Fiscal Year Final Research Report
Identification of new therapeutic target for chronic kidney diseases
| Project/Area Number |
23890085
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Kidney internal medicine
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
KUME Shinji 滋賀医科大学, 医学部, 特任助教 (00452235)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 慢性腎臓病 / 肥満 / 老化 |
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| Research Abstract |
In glomerular diseases, reducing proteinuria is considered as a principal therapeutic target to improve renal outcomes.. Unfortunately, however, some patients develop treatment-resistant proteinuria, resulting in end stage renal disease. In these patients, protecting proximal tubular epithelial cells (PTECs) against proteinuria may be the next therapeutic target to improve renal outcomes. Obesity and aging are independent risk factors for a rapid decline in renal function inpatients with glomerular diseases. Since the severity of proteinuria-induced tubulointerstitial lesions is correlated with renal outcomes, obesity and aging may exacerbate proteinuria-induced tubulointerstitial lesions. If so, identifying the molecular mechanisms underlying obesity- and aging-mediated PTEC vulnerability may lead to new therapy that improves renal outcome in patients with proteinuria. We thus tried to identify a new therapeutic candidate genes by using cDNA microarray analysis in the kidney samples from obese and aged mice with proteinuria. In this study, we have identified a new candidate gene involved in the mechanism underlying obesity- and aging-mediated worsening of proteinuria-induced tubulointerstitial lesion
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Research Products
(22 results)
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[Journal Article] Emerging role of autophagy in kidney function, diseases and aging2012
Author(s)
Huber TB, Edelstein CL, Hartleben B, Inoki K, Jiang M, Koya D, Kume S, Lieberthal W, Pallet N, Quiroga A, Ravichandran K, Susztak K, Yoshida S, Dong Z.
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Journal Title
DOI
Peer Reviewed
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[Journal Article] a PPARδ agonist, ameliorates tubulointerstitial inflammation in proteinuric kidney disease via inhibition of TAK1-NFκB pathway in mice2011
Author(s)
Yang X, Kume S, Tanaka Y, Isshiki K, Araki S, Chin-Kanasaki M, Sugimoto T, Koya D, Haneda M, Sugaya T, Li D, Han P, Nishio Y, Kashiwagi A, Maegawa H, Uzu T. GW501516
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Journal Title
PLoS One
Volume: 6(9):e25271
DOI
Peer Reviewed
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[Journal Article] SIRT3 attenuates palmitate-induced ROS production and inflammation in proximal tubular cells.2011
Author(s)
Koyama T, Kume S, Koya D, Araki S, Isshiki K, Chin-Kanasaki M, Sugimoto T, Haneda M, Sugaya T, Kashiwagi A, Maegawa H, Uzu T.
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Journal Title
Free Radic Biol Med
Volume: 51(6)
Pages: 1258-67
DOI
Peer Reviewed
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[Journal Article] Fenofibrate, a PPARα agonist, has renoprotective effects in mice by enhancing renal lipolysis2011
Author(s)
Tanaka Y, Kume S, Araki S, Isshiki K, Chin-Kanasaki M, Sakaguchi M, Sugimoto T, Koya D, Haneda M, Kashiwagi A, Maegawa H, Uzu T
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Journal Title
Kidney Int
Volume: 79(8)
Pages: 871-82
DOI
Peer Reviewed
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[Presentation]2012
Author(s)
久米真司
Organizer
第12回日本抗加齢医学会総会
Place of Presentation
横浜
Year and Date
20120600
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[Presentation]2012
Author(s)
久米真司
Organizer
第55回日本腎臓学会学術総会
Place of Presentation
横浜
Year and Date
20120600
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[Presentation]2012
Author(s)
久米真司
Organizer
第55回日本糖尿病学会年次学術集会
Place of Presentation
横浜
Year and Date
20120200
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