2012 Fiscal Year Final Research Report
Searching and functional analysis of an intracellular DNA sensor
| Project/Area Number |
23890088
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | Kyoto University |
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Principal Investigator |
MOTANI Kou 京都大学, 医学研究科, 研究員 (70609049)
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| Project Period (FY) |
2011 – 2012
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| Keywords | STING |
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| Research Abstract |
Accumulation of undigested self-DNA in cells causes chronic inflammation and rheumatoid arthritis. The purpose of this study is to elucidate the mechanism in which undigested self-DNA is recognized and causes inflammation. To identify an unknown intracellular DNA senor, cells were screened and I obtained cell clones which produced high amount of inflammatory cytokines in response to DNA. Moreover, I found that STING molecule was activated by DNA and required for self-DNA-induced inflammatory response.
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