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2012 Fiscal Year Final Research Report

Analysis of extramedullary microenvironment includingcentral nerve system of leukemic cells

Research Project

  • PDF
Project/Area Number 23890092
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Pediatrics
Research InstitutionKyoto University

Principal Investigator

KATO Itaru  京都大学, 医学研究科, 特定病院助教 (10610454)

Project Period (FY) 2011 – 2012
Keywords白血病 / 中枢神経再発 / 微小環境
Research Abstract

Bone marrow samples from ALL patients were transplanted into NOG mouse and extramedullary organs including CNS showed the leukemic invasion. In the CNS, we observed the infiltration of leukemic cells that is consistent with pathology of human ALL patients. Several analyses suggest that our model recapitulates the CNS disease and histopathology of human ALL leukemic CNS. To identify genes involved in CNS leukemia development, we applied high-density oligonucleotide arrays to leukemic cells in CNS and BM. A series of CNS leukemic cell-specific gene sets have been successfully identified. Next, we transplanted leukemic cells harvested from CNS into NOG mice, and leukemic cells reconstitute the leukemia. Those results showed that leukemic cells in CNS contributed to the relapse of the disease with altering the gene expressionpattern. This information could be utilized for further mechanistic research and for devising optimized therapeutic strategies against CNS leukemia.

  • Research Products

    (7 results)

All 2013 2012 2011 Other

All Journal Article (2 results) Presentation (4 results) Remarks (1 results)

  • [Journal Article] Clonal selection in xenografted TAM recapitulates the evolutionary process of myeloid leukemia in Down syndrome2013

    • Author(s)
      Saida S, Watanabe KI, Sato-Otsubo A, Terui K, Yoshida K, Okuno Y, Toki T, Wang R, Shiraishi Y, Miyano S, Kato I, et al
    • Journal Title

      Blood

    • DOI

      doi:10.1182/blood-201212-474387

  • [Journal Article] dentification of Hepatic Niche Harboring Human Acute Lymphoblastic Leukemic Cells via the SDF-1/CXCR4 Axis2011

    • Author(s)
      Kato I, Niwa A, Heike T, et al
    • Journal Title

      PLoS One

      Volume: 6 Pages: e27042

    • DOI

      doi:10.1371/journal.pone.0027042

  • [Presentation] Analysis of extramedullary microenvironment of leukemic cells through NOD/SCID/γc Null Mouse Xenograft Model transplanted with Patient-Derived Acute Lymphoblastic Leukemic Cells;1st Samsung Humanized Mice Symposium2012

    • Author(s)
      Kato I, et al
    • Organizer
      Samsung Seoul Hospital
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2012-04-14
  • [Presentation] Leukemic cells in the extramedullary site contribute to the relapse of the disease2012

    • Author(s)
      Kato I,et al
    • Organizer
      11th Interim Meeting of the I-BFM Resistant Disease Committee
    • Place of Presentation
      Rome
    • Year and Date
      2012-02-10
  • [Presentation] Analysis of extramedullary microenvironment of leukemic cells through NOD/SCID/γc Null Mouse Xenograft Model transplanted with Patient-Derived Acute Lymphoblastic Leukemic Cells2011

    • Author(s)
      Kato I, et al
    • Organizer
      3rd International workshop on Humanized Mice
    • Year and Date
      2011-10-28
  • [Presentation] Analysis of CNS Leukemic Microenviroments through Xenograft Model In NOG Mouse2011

    • Organizer
      第73回 日本血液学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-14
  • [Remarks]

    • URL

      http://www.kuhp.kyoto-u.ac.jp/~pediatrics/

URL: 

Published: 2014-08-29  

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