Analysis of epigenetics induced by Interleukin 6

2012 Fiscal Year Final Research Report

• Project/Area Number: 23890098
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Immunology
• Research Institution: Osaka University
• Principal Investigator: ISOBE Tomoyasu 大阪大学, 大学院・工学研究科, 特任助教 (40402341)
• Project Period (FY): 2011 – 2012
• Keywords: 炎症 / エピジェネティクス

Research Abstract

In chronic inflammation disease, constitutively produced inflammatory cytokines perturb various gene expression mechanisms. We focused on epigenetic regulation of gene expression, and found several modifications on histone which were specifically altered by IL-6. On the other hand, we proposed a novel model which could explain aberrant regulation of epigenetics in inflammatory-associated cancer.

Research Products

• [Journal Article] Prediction and experimental validation of putative non-consensus binding site for transcription factor STAT3 in Serum amyloid A gene promoter. (2013)
  • Author(s): Tiwari, P., Tripathi, LP., Nishikawa-Matsumura, T., Ahmad, S., Soken-Nakazawa, J-S., Isobe, T., Mizuguchi, K. and Yoshizaki, K.
  • Journal Title: Biochim Biophys Acta Volume: 1830 Pages: 3650-3655
• [Journal Article] Activation-induced cytidine deaminase auto-activates and triggers aberrant gene expression.
  • Author(s): Isobe, T., Soken-Nakazawa, J-S., Tiwari, P., Ito, H., Yamaguchi Y. and Yoshizaki, K.
  • Journal Title: FEBS Lett Volume: (in press)