2012 Fiscal Year Final Research Report
Analysis of epigenetics induced by Interleukin 6
Project/Area Number |
23890098
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Single-year Grants |
Research Field |
Immunology
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Research Institution | Osaka University |
Principal Investigator |
ISOBE Tomoyasu 大阪大学, 大学院・工学研究科, 特任助教 (40402341)
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Project Period (FY) |
2011 – 2012
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Keywords | 炎症 / エピジェネティクス |
Research Abstract |
In chronic inflammation disease, constitutively produced inflammatory cytokines perturb various gene expression mechanisms. We focused on epigenetic regulation of gene expression, and found several modifications on histone which were specifically altered by IL-6. On the other hand, we proposed a novel model which could explain aberrant regulation of epigenetics in inflammatory-associated cancer.
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[Journal Article] Prediction and experimental validation of putative non-consensus binding site for transcription factor STAT3 in Serum amyloid A gene promoter.2013
Author(s)
Tiwari, P., Tripathi, LP., Nishikawa-Matsumura, T., Ahmad, S., Soken-Nakazawa, J-S., Isobe, T., Mizuguchi, K. and Yoshizaki, K.
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Journal Title
Biochim Biophys Acta
Volume: 1830
Pages: 3650-3655
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