2012 Fiscal Year Final Research Report
An analysis of the enhancement mechanism of antitumor cytotoxic T cells by B7.2
| Project/Area Number |
23890106
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 腫瘍免疫 / 細胞障害性T細胞 |
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| Research Abstract |
We cultured spleen cells and B 7.2 of the cancer bearing mouse. As a result, we were able to induce CTL in a high ratio in a certain tumor. However, CTLA-4 was not associated with an induction mechanism of the CTL. It was suggested that stimulation to CD28 by B7．2 was a main pathway to CTL induction in our study. Also, we investigate the enhancement effect with the immunostimulation nutrient for enhancement of antitumor CTL.
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Research Products
(12 results)
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[Journal Article] A case of malignant melanoma discovered as a result of metastatic disease of the temporomandibular joint.2013
Author(s)
YasunariMorimoto, Suguru Hamada,Takafumi,Ogura,HirokazuNakahara, Akifumi,Enomoto,Takayuki Uchihashi,Shin-ichiro Hiraoka,MIkihiko Kogo
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Journal Title
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology
Volume: Volume 25, Issue 1
Pages: 74-78
Peer Reviewed
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[Journal Article]2012
Author(s)
浜口裕弘, 松岡裕大, 磯村恵美子, 永谷俊介,占部一彦, 川嵜康大, 西野仁, 平岡慎一郎, 鏡内 肇
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Journal Title
大阪大学歯学会雑誌
Volume: 56巻2号
Pages: 119-122
Peer Reviewed
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