2012 Fiscal Year Final Research Report
Gene polymorphism in PLAP-1regulates inflammation of periodontal disease.
| Project/Area Number |
23890109
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Periodontal dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | PLAP-1 / 歯根膜 / 遺伝子多型 / 歯周炎 / 疾患感受性 |
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| Research Abstract |
PLAP-1 inhibited LPS-induced inflammation with mouse periodontal ligament cells(MPDL22). In addition, the D14 allele of PLAP-1 inhibited LPS-induced inflammation more strongly compared to the D13 allele of PLAP-1. However, there was no significant difference of LPS-induced inflammation between PLAP-1 deficient mice and wild type mice. Now, I try to make the mouse model of periodontal disease which can elucidate the correlation between polymorphism in PLAP-1 and periodontal inflammation with D13- and D14-PLAP-1 expressing adenovirus system.
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