2012 Fiscal Year Final Research Report
Effects of polyols on periodontopathic biofilm development
| Project/Area Number |
23890112
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Social dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
HASHINO Ei 大阪大学, 歯学部附属病院, 特任助教 (90614553)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 糖アルコール / 歯周病細菌 / バイオフィルム / メタボローム解析 |
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| Research Abstract |
Our previous study showed that sugar alcohols(polyols) such as erythritol inhibited Streptococcus gordonii-Porphyromonas gingivalisbiofilm formation and erythritol was the most effective reagent to reduce P. gingivalisas compared with other tested polyols. To examine the inhibitory effects of erythritol, we analyzed the metabolomic profiles of erythritol-treated P. gingivalis and S. gordonii cells. These results suggest that erythritol has inhibitory effects on dual species biofilm development via several pathways, including suppression of growth resulting from DNA and RNA depletion and alteration of central carbon metabolism.
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