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2012 Fiscal Year Final Research Report

The functional analysis of WISP-1 gene in osteoarthritis and chondrogenic differentiation.

Research Project

  • PDF
Project/Area Number 23890122
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Prosthetic dentistry
Research InstitutionOkayama University

Principal Investigator

ONO Mitsuaki  岡山大学, 大学院・医歯薬学総合研究科, 助教 (60613156)

Project Period (FY) 2011 – 2012
Keywords軟骨分化 / WISP-1
Research Abstract

The purpose of this study was to clarify the relationship between WISP-1 gene and osteoarthritis (OA). First, we analyzed the knee joint histologically, and OA like condition was observed in WISP-1 KO mice. Moreover, overexpression of WISP-1 enhanced the chondrogenic differentiation in human bone marrow stromal cells. These data show that WISP-1 could be involved in the onset of OA by regulating the chondrogenic differentiation.

  • Research Products

    (6 results)

All 2012 2011

All Presentation (6 results)

  • [Presentation] CCN3/NOVの軟骨特異的過剰発現は軟骨分化の最終段階に影響を及ぼすことにより骨形成不全をきたす2012

    • Author(s)
      服部高子,大野充昭
    • Organizer
      第85回日本生化学会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-16
  • [Presentation] 皮膚創傷治癒過程におけるCCN4/WISP-1遺伝子の役割2012

    • Author(s)
      正木明日香,大野充昭
    • Organizer
      第10回日本再生歯科医学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2012-09-02
  • [Presentation] WISP-1/CCN4: Potential Regulation of Mineralized Tissue through Modulation of Wnt Signaling.2012

    • Author(s)
      Maeda A.Ono M
    • Organizer
      第30回日本骨代謝学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2012-07-20
  • [Presentation] WISP-1/CCN4: Potential Regulation of Mineralized Tissue through Modulation of Wnt Signaling2012

    • Author(s)
      Maeda A.Ono M
    • Organizer
      National Institute of Dental and Craniofacial Research 6th Annual Fellows Retreat
    • Place of Presentation
      Chamberland, USA
    • Year and Date
      2012-04-19
  • [Presentation] Determiningthe function of WISP-1/CCN4 in mineralized tissue2011

    • Author(s)
      Maeda A.Ono M
    • Organizer
      American Society for Bone and Mineral Research 2011Annual Meeting
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2011-09-18
  • [Presentation] Determiningthe function of WISP-1/CCN4 in mineralized tissue2011

    • Author(s)
      Maeda A.Ono M
    • Organizer
      National Institute of Dental and Craniofacial Research 5th Annual Fellows Retreat
    • Place of Presentation
      Chamberland, USA
    • Year and Date
      2011-04-14

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Published: 2014-08-29  

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