2012 Fiscal Year Final Research Report

Investigation of the mechanisms involving BMP-2-induced inhibition of bone formation or niche formation at the bone marrow microenvironment.

Research Project

Project/Area Number	23890123
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Dental engineering/Regenerative dentistry
Research Institution	Okayama University
Principal Investigator	NAWACHI Kumiko 岡山大学, 岡山大学病院, 助教 (10379787)
Research Collaborator	OIDA Yasutaka 岡山大学, 岡山大学病院, 医員 (50625720) SONOYAMA Wataru 岡山大学, 大学院・医歯薬学総合研究科, 助教 (40325121) KUBOKI Takuo 岡山大学, 大学院・医歯薬学総合研究科, 教授 (00225195)
Project Period (FY)	2011 – 2012
Keywords	BMP-2 / 骨髄 / 血球系細胞
Research Abstract	BMP-2 is widely known as an osteogenic inducer, but conflicting results are related to its function inside the bone marrow space. This study aimed to clarify the molecular mechanisms and impact of BMP-2 on bone metabolism environment of the bone marrow space. Of great interest, we found that BMP-2 inhibits bone formation in bone marrow space. To date, in an attempt to elucidate this mechanism, we are focusing on BMP-2 negative feedback regulation as well as on cellular and molecular interactions from an immunological perspective.

(5 results)