2012 Fiscal Year Final Research Report
Investigation of the role of SSEA-4 in human periodontal ligament stem cells
| Project/Area Number |
23890126
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Kochi University (2012)
Okayama University (2011) |
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Principal Investigator |
MURATA Satoko 高知大学, 医学部附属病院, 医員 (00610916)
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| Project Period (FY) |
2011 – 2012
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| Keywords | ヒト歯根膜細胞 / Stage-specific embryonic antigen-4 / Serine palmitoyltransferase / Glucosylceramide synthetase |
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| Research Abstract |
In the present study, we investigated whether SSEA-4 synthesis is involved in maintenance and differentiation of human periodontal ligament (PDL) stem cells. Our results demonstrated that the blockade of serine palmitoyltransferas and glucosylceramide synthetase ,which are involved in SSEA-4 synthesis, affected adipogenic/osteogenic potential of human PDL stem cells. Hence, SSEA-4 synthesis appears to be involved in maintenance and differentiation of human PDL stem cells.
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