2012 Fiscal Year Final Research Report
Investigation of the enhancement of periodontal regeneration by inhibition of gingival downgrowth by Smad2 overexpression
| Project/Area Number |
23890128
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Periodontal dentistry
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| Research Institution | Kyushu University (2012)
Okayama University (2011) |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 歯学 / 再生医学 / 細胞・組織 / マイクロアレイ |
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| Research Abstract |
We made alveolar bone defect in mouse by the mechanical way to inhibit gingival downgrowth. But we modified the way to suit clinical situation. Finally, the mouse model was established by infection of periodontopathic bacteria, we could confirm a clear alveolar bone defect by CT scan. Additionally our findings indicated that healing of periodontal connective tissue was promoted in TG as compared with WT.
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