2012 Fiscal Year Final Research Report
Regulation of cytotoxic activity of liver NK cells against islet graft
| Project/Area Number |
23890132
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
General surgery
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| Research Institution | Hiroshima University |
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Principal Investigator |
ISHIYAMA Kohei 広島大学, 医歯薬保健学研究院, 特任助教 (50437589)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 膵島移植 / NK 細胞 |
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| Research Abstract |
Islet transplantation becomes one of the therapeutic option for cure of type 1 diabetes. In this study, we have researched the possibility of regulation of natural killer cells cytotoxicity against transplanted islet graft. Co-culture with both prostaglandin E2 and TGF-beta can suppress the cytokine stimulated-NK cells cytotoxicity.
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Research Products
(6 results)
