2012 Fiscal Year Final Research Report
Elucidation of target-specific mechanisms of phagosome formation through distinct receptors.
| Project/Area Number |
23890144
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Fukuoka University (2012)
Kagawa University (2011) |
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Principal Investigator |
FUJII Makoto 福岡大学, 医学部, 講師 (30398086)
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| Project Period (FY) |
2011 – 2012
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| Keywords | ファゴサイトーシス / ライブセルイメージング |
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| Research Abstract |
Phagocytosis of pathogen and extracellular particles by macrophages is an important for immune system. In this study, we investigated the relationship between phagosome formation and signaling pathway using different phagocytotic targets. We found that Rab35, one of the small GTPase which involved in intracellular membrane trafficking, had pivotal role in TLR2 and FcR mediated phagocytosis.
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