The role of Leukotrine B4 in dendritic cell-T cell interaction

2012 Fiscal Year Final Research Report

• Project/Area Number: 23890146
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: General medical chemistry
• Research Institution: Juntendo University (2012); Kyushu University (2011)
• Principal Investigator: KOGA Tomoaki 順天堂大学, 医学部, 助教 (30615092)
• Project Period (FY): 2011 – 2012
• Keywords: GPCR / 樹状細胞 / T 細胞 / 生理活性脂質

Research Abstract

I revealed the important role of LTB4-BLT1 axis in antigen-dependent immunological synapse (IS) formation between dendritic cells (DC) and CD4+T cells. By using in vitroDC-T cell co-culture system, I also found that BLT1 in DC is important for IS formation. In parallel, to investigate the role of BLT1 in DC in vivo, I established the BLT1floxedmice. I will generate DC-specific BLT1 conditional knockout mice.

Research Products

• [Journal Article] Suppression of inflammation viaPDE4B-JNK2-dependent upregulation of deubiquitinase CYLD (2013)
  • Author(s): Komatsu K, Lee J, Miyata M, Lim JH, Jono H, Koga T, Xu H, Yan C, Kai H, Li JD
  • Journal Title: Nature Commun Volume: 4 Pages: 4:1684
• [Journal Article] Insulin receptor activation through its accumulation in lipid rafts by mild electrical stress (2013)
  • Author(s): Morino-Koga S, Yano S, Kondo T, Shimauchi Y, Matsuyama S, Okamoto Y, Suico MA, Koga T, Sato T, Shuto T, Arima H, Wada I, Araki E, Kai H
  • Journal Title: J Cell Physiol Volume: 228(2) Pages: 439-446
• [Journal Article] Mild electrical stimulation and heat shock ameliorates progressive proteinuria and renal inflammation in mouse model of Alport syndrome (2012)
  • Author(s): Koga T, Kai Y, Fukuda R, Morino-Koga S, Suico MA, Koyama K, Sato T, Shuto T, Kai H
  • Journal Title: PLoS ONE Volume: 7(8) Pages: e43852
• [Journal Article] STT3B-dependent posttranslational N- glycosylation as a sruceillance system for secretory protein (2012)
  • Author(s): Sato T, Sako Y, Sho M, Momohara M, Suico MA, Shuto T, Nishitoh H, Okiyoneda T, Kokame K, Kaneko M, Taura M, Miyata M, Chosa K, Koga T, Morino-Koga S, Wada I, Kai H
  • Journal Title: Mol Cell Volume: 47(1) Pages: 99-110
• [Journal Article] (2012)
  • Author(s): Lim JH, Jono H, Komatsu K, Woo CH, Lee J, Miyata M, Matsuno T, Xu X, Huang Y, Zhang W, Park SH, Kim YI, Choi YD, Shen H, Heo KS, Xu H, Bourne P, Koga T, Xu H, Yan C, Wang B, Chen LF, Feng XH, Li JD.
  • Journal Title: Nature Commun Pages: 3:771
• [Journal Article] Lucidenic acids-rich extract from antlered form of Ganoderma lucidum enhances TNF-alpha induction in THP-1 monocytic cells possibly via its modulation of MAP kinases p38 and JNK. (2011)
  • Author(s): Watanabe K, Shuto T, Sato M, Onuki K, Mizunoe S, Suzuki S, Sato T, Koga T, Suico MA, Kai H, Ikeda T.
  • Journal Title: Biochem Biophys Res Commun Volume: 408(1) Pages: 18-24
• [Remarks]
  • URL: http://plaza.umin.ac.jp/j_bio/Biochem1/
• [Remarks]
  • URL: https://www.juntendo.ac.jp/graduate/kenkyudb/search/researcher.php?MID=4838