2012 Fiscal Year Final Research Report
Role of interferon regulatory factor(IRF) family transcription factor in microglial activation and neuropathic pain.
Project/Area Number |
23890148
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Research Category |
Grant-in-Aid for Research Activity Start-up
|
Allocation Type | Single-year Grants |
Research Field |
Pain science
|
Research Institution | Kyushu University |
Principal Investigator |
|
Project Period (FY) |
2011 – 2012
|
Keywords | ミクログリア / 神経障害性疼痛 / IRF / 転写因子 / 中枢性疾患 / P2X4受容体 |
Research Abstract |
We identify the interferon regulatory factor (IRF) member IRF8-IRF5 axis as a critical transcriptional regulator of microglia involved in converting into a P2X4R^hireactive phenotype, which drives neuropathic pain following peripheral nerve injury.
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