2012 Fiscal Year Final Research Report
Regulatory mechanism of EGF Receptor endocytosis by membrane deformingprotein FCHO2
| Project/Area Number |
23890162
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
General medical chemistry
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | EGF 受容体 / エンドサイト-シス / ユビキチン化 |
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| Research Abstract |
Endocytosis plays a critical role in the signal transduction,degradation, and recycling of EGF receptor. It is thus important to elucidate the basicprocess of endocytosis. We have studied the molecular mechanisms of F-BAR domaincontaining protein FCHO2 in the regulation of endocytosis and recently found its rolein the activation of ubiqutin ligase Nedd4L. Here we studied about the involvement ofadaptor molecule ARRDC1 in the FCHO2/Nedd4L mediated endocytosis process and revealedthat the localization of Nedd4L on plasma membrane, which is essential for its activation, is regulated by ARRDC1 and FCHO2 cooperatively.
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