2011 Fiscal Year Final Research Report
DAMPs : novel molecular targets for DIC therapy
| Project/Area Number |
23890166
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Emergency medicine
|
|---|
| Research Institution | Kagoshima University |
|---|
Principal Investigator |
ITO Takashi 鹿児島大学, 医歯学総合研究科, 特任講師 (20381171)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
MARUYAMA Ikuro 鹿児島大学, 大学院・医歯学総合研究科システム血栓制御学(メディポリス連携医学)講座, 特任講師 (20082282)
KAWAHARA Ko-ichi 大阪工業大学, 工学部・生命工学科機能性食品研究室, 特任教授 (10381170)
|
|---|
| Research Collaborator |
NAKAHARAA Mayumi 鹿児島大学, 大学院・医歯学総合研究科救急・集中治療医学分野, 医員
NAGASATO Tomoka 鹿児島大学, 大学院・医歯学総合研究科システム血栓制御学(メディポリス連携医学), 講座
|
|---|
| Project Period (FY) |
2011
|
| Keywords | DAMPs / 血栓形成 / 敗血症 / DIC / ヒストン / トロンボモジュリン |
|---|
| Research Abstract |
Histones, abundant proteins in the nucleus, are released into the extracellular space during sepsis. In this study we found that extracellular histones triggered platelet aggregation, leading to thrombotic occlusion of pulmonary capillaries in mice. These mice displayed signs of disseminated intravascular coagulation(DIC), including thrombocytopenia, prolonged prothrombin time, decreased fibrinogen, fibrin deposition in capillaries, and bleeding symptoms. Recombinant thrombomodulin, a newly approved drug for DIC in Japan, prevented histone-mediated platelet aggregation and protected mice against histone-induced fatal thromboembolism.
|
