2012 Fiscal Year Final Research Report
Effects of controlled release of NF-k8 inhibitor on bone regeneration
| Project/Area Number |
23890194
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Conservative dentistry
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
TSUCHIYA Shizu 九州歯科大学, 歯学部歯学科, 助教 (60610053)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 炎症 / NF-kB / 骨形成 |
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| Research Abstract |
We examined effects of steroid-coactivator MTI-II on inflammatory responses in MG63 cells. Overexpression of MTI-II in he cells failed toincrease TNFa-induced NF-k8-luciferase activity in a dose-dependent manner as well as TNFa-induced expression of matrix metallopeptidase-9 (MMP-9) mRNA , a target gene of NF-kB. These results suggest that MT1-II may may have an potential as an anti-inflaammatory drug
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