2012 Fiscal Year Final Research Report
Development of a new therapy for xerostomia using mechanobiology
| Project/Area Number |
23890195
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Prosthetic dentistry
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
KONDO Yusuke 九州歯科大学, 歯学部, 助教 (00611287)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 唾液腺 / 顎下腺 / 口腔乾燥症 / メカノバイオロジー |
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| Research Abstract |
I planned this study to develop a new therapy for xerostomia using mechanobiologycombined with muscarinic agonists. As a result, it was revealed that salivary gland function is temperature-sensitive, which is associated with intracellular Ca2+concentration increase. In addition, it is also clarified that the saliva secretion is updated in hypotonic environment, and the involvement of Na+-K+-2Clcotransporter activity has been suggested as the cause.
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