2012 Fiscal Year Final Research Report
Combinatorial Synthesis of Bottromycin A2 and Development of New Anti MRSA Agent
| Project/Area Number |
23890202
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kitasato University |
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Principal Investigator |
YAMADA Takeshi 北里大学, 大学院・感染制御科学府, 助教 (00608367)
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| Project Period (FY) |
2011 – 2012
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| Keywords | ボトロマイシン / ペプチド合成 / アミジン / 抗 MRSA / 抗 VRE |
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| Research Abstract |
We have developed the convergent synthetic route to bottromycins (BTMs), which exhibit a potent antibiotic activity against MRSAand VRE with novel mode of action. In the course of SAR study, we found the methyl groups of unnatural amino acids, 3-Me-Pro and 3-Me-Phe, are the important functionality for their biological activities. The three-dimensional structure of BTM was investigated to improve understanding of SAR, and to design the new BTM analog which reveals the potent antibiotic activity.
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[Presentation] Bottromycin A_2 の全合成と誘導体合成研究2012
Author(s)
小林 豊, 市岡真季, 廣瀬友靖, 山田 健, 長井賢一郎, 合田浩明, 島村寛章, 花木秀明, 広野修一, 大村 智, 砂塚敏明
Organizer
第15回北里微生物アカデミー研究集会
Place of Presentation
北里大学白金キャンパス
Year and Date
2012-08-02
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[Presentation] Bottromycin A_2 の全合成と誘導体合成研究2012
Author(s)
小林 豊, 市岡真季, 廣瀬友靖, 山田 健, 長井賢一郎, 合田浩明, 島村寛章, 花木秀明, 広野修一, 大村 智, 砂塚敏明
Organizer
第10回次世代を担う有機化学シンポジウム
Place of Presentation
大阪大学吹田キャンパス
Year and Date
2012-05-12
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[Presentation] Bottromycin A_2 を模倣した新規抗MRSA 活性物質の創製、AKPS 集会2011
Author(s)
山田 健, 井手口哲也, 千成 恒, 小林 豊, 廣瀬友靖, 松井秀仁, 花木秀明, 合田浩明, 小林義典, 広野修一, 大村 智, 砂塚敏明
Organizer
第7回北里化学シンポジウム
Place of Presentation
北里大学白金キャンパス
Year and Date
2011-12-22
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