2012 Fiscal Year Final Research Report
Molecular mechanism of xerostomia through diazepam binding inhibitor (DBI) in rat salivary glands
| Project/Area Number |
23890213
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional basic dentistry
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| Research Institution | Tokyo Dental College |
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Principal Investigator |
TSUKAGOSHI Eri 東京歯科大学, 歯学部, 非常勤講師 (60615384)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 歯科薬理学 |
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| Research Abstract |
In this study, we investigated the effects of repetitive administration of diazepam (DZP) on expression of PAC1-R and CYP11A1 mRNA in rat salivary glands. The present study has shown clearly that repetitive administration of DZP increased expression of PAC1-R and CYP11A1 mRNA and decreased secretion of saliva in rat salivary gland. These results suggest that repetitive administration of DZP stimulates PAC1-R and CYP11A1 expression, which may result in an increase in the suppressive effect of DZP on salivary secretion.
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